Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours. Acetaminophen and alcohol: Safety and risks Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. About 1.8% of children exposed to Tylenol during pregnancy developed autism compared to 3.0% of those who were not exposed to Tylenol. Tap the link in our bio for more. Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect